Standard Name	AIP1 1
Systematic Name	YMR092C
Feature Type	ORF, Verified
Description	Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress (2, 3, 4)
Name Description	Actin Interacting Protein 1

Chromosomal Location	ChrXIII:453479 to 451632 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for AIP1
Molecular Function
Manually curated	actin binding (IPI)
Biological Process
Manually curated	actin filament depolymerization (IGI, IPI) response to osmotic stress (TAS)
Cellular Component
Manually curated	actin cortical patch (IDA)
High-throughput	cytoplasm (IDA) mating projection tip (IDA) nucleus (IDA)

Classical genetics
null	resistance to ethanol: decreased viable
unspecified	actin cytoskeleton morphology: abnormal
Large-scale survey
null	auxotrophy competitive fitness: decreased endocytosis: decreased haploproficient hyperosmotic stress resistance: decreased resistance to ethanol: decreased viable
overexpression	filamentous growth: increased invasive growth: absent
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	58 total interaction(s) for 31 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1 Protein-peptide: 3 Reconstituted Complex: 1 Two-hybrid: 10
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 23 Phenotypic Enhancement: 1 Positive Genetic: 1 Synthetic Growth Defect: 7 Synthetic Lethality: 5 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:453479 to 451632 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1848 453479..451632 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004698