MIC12/YBR262C Summary Help

Standard Name MIC12 1
Systematic Name YBR262C
Alias FMP51 2 , MCS12 3 , AIM5 4
Feature Type ORF, Verified
Description Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (3, 5, 6)
Name Description MItochondrial contact site and Cristae organizing system 1
Chromosomal Location
ChrII:736040 to 735720 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MIC12 GO evidence and references
  View Computational GO annotations for MIC12
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
59 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-RNA: 5
  • Affinity Capture-Western: 17
  • Co-purification: 3

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 13
  • Positive Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 106
Molecular Weight (Da) 12,388
Isoelectric Point (pI) 9.1
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:736040 to 735720 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..321 736040..735720 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000466
References cited on this page View Complete Literature Guide for MIC12
1) Pfanner N, et al.  (2014) Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol 204(7):1083-6
2) Rehling, P., et al.  (2004) personal communication
3) Harner M, et al.  (2011) The mitochondrial contact site complex, a determinant of mitochondrial architecture.LID - 10.1038/emboj.2011.379 [doi] EMBO J ()
4) Hess DC, et al.  (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407
5) von der Malsburg K, et al.  (2011) Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev Cell 21(4):694-707
6) Hoppins S, et al.  (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol 195(2):323-40