AGP1/YCL025C Summary Help

Standard Name AGP1 1
Systematic Name YCL025C
Alias YCC5 1
Feature Type ORF, Verified
Description Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication (1, 2, 3)
Name Description high-Affinity Glutamine Permease 1
Chromosomal Location
ChrIII:77919 to 76018 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All AGP1 GO evidence and references
  View Computational GO annotations for AGP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 17 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
146 total interaction(s) for 117 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • PCA: 37

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 77
  • Phenotypic Enhancement: 2
  • Positive Genetic: 17
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 633
Molecular Weight (Da) 69,671
Isoelectric Point (pI) 6.95
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:77919 to 76018 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
This feature contains embedded feature(s): YCLX09W
SGD ORF map
Last Update Coordinates: 2006-01-12 | Sequence: 2006-01-12
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1902 77919..76018 2006-01-12 2006-01-12
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000000530
References cited on this page View Complete Literature Guide for AGP1
1) Schreve JL, et al.  (1998) The Saccharomyces cerevisiae YCC5 (YCL025c) gene encodes an amino acid permease, Agp1, which transports asparagine and glutamine. J Bacteriol 180(9):2556-9
2) Forsberg H, et al.  (2001) The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids. Mol Microbiol 42(1):215-28
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61