AGE2/YIL044C Summary

AGE2 BASIC INFORMATION

Standard Name	AGE2
Systematic Name	YIL044C
Alias	SAT2
Feature Type	ORF, Verified
Description	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif (1, 2, 3)
Name Description	Arf Gap with Effector function(s)

GO Annotations	All AGE2 GO evidence and references
	View Computational GO annotations for AGE2
Molecular Function
Manually curated	ARF GTPase activator activity (IDA, IGI, ISS)
Biological Process
Manually curated	ER to Golgi vesicle-mediated transport (IGI, ISS) intra-Golgi vesicle-mediated transport (IGI, ISS)
Cellular Component
High-throughput	colocalizes_with clathrin-coated vesicle (IDA)

Mutant Phenotype	All AGE2 Phenotype details and references
Large-scale survey
null	inositols excretion: increased competitive fitness: decreased hyperosmotic stress resistance: decreased viable

Interactions	AGE2 All interactions details and references
	39 total interaction(s) for 20 unique genes/features.
Physical Interactions	Biochemical Activity: 2 PCA: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Phenotypic Enhancement: 22 Phenotypic Suppression: 6 Synthetic Growth Defect: 3 Synthetic Lethality: 3

Sequence Information

ChrIX:273845 to 272949 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..897	273845..272949	1994-12-10	1994-12-10

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001306

AGE2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for AGE2

NOMENCLATURE CONFLICT NOTE

Name	Relevance	Description
ARE1	Nomenclature conflict	SAT2 has been used in the literature to refer to both ARE1/YCR048W, which encodes a sterol O-acyltransferase, and AGE2/YIL044C, which encodes an ARF GTPase activator.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for AGE2]

1)	Zhang CJ, et al. (1998) A family of Arf effectors defined as suppressors of the loss of Arf function in the yeast Saccharomyces cerevisiae. J Biol Chem 273(31):19792-6
2)	Poon PP, et al. (2001) The Gcs1 and Age2 ArfGAP proteins provide overlapping essential function for transport from the yeast trans-Golgi network. J Cell Biol 155(7):1239-50
3)	Zhang CJ, et al. (2003) Four ARF GAPs in Saccharomyces cerevisiae have both overlapping and distinct functions. Yeast 20(4):315-30

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