AGC1/YPR021C Summary Help

AGC1 BASIC INFORMATION

Standard Name AGC1 1
Systematic Name YPR021C
Feature Type ORF, Verified
Description Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis (1 and see Summary Paragraph)
Name Description Aspartate-Glutamate Carrier 1
GO Annotations All AGC1 GO evidence and references
    View Computational GO annotations for AGC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All AGC1 Phenotype details and references
Classical genetics
null
Large-scale survey
overexpression
Interactions AGC1 All interactions details and references
5 total interaction(s) for 5 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Two-hybrid: 2
Genetic Interactions
  • Synthetic Growth Defect: 2
Sequence Information
ChrXVI:603354 to 600646 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-07-21 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2709 603354..600646 2004-07-21 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | TCDB | UniProtKB
Primary SGDIDS000006225

AGC1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for AGC1

SUMMARY PARAGRAPH for AGC1

AGC1 encodes a mitochondrial inner membrane aspartate/glutamate transporter that contributes to the biosynthesis of nitrogen compounds (1, 2). Agc1p is orthologous to the human proteins aralar (encoded by SLC25A12 (OMIM)) and citrin (encoded by SLC25A13 (OMIM)). Like the human orthologs, Agc1p can act as an aspartate-glutamate antiporter. In contrast to the human orthologs, Agc1p also functions as a uniporter for both glutamate and aspartate, it does not contain an N-terminal EF-hand Ca++-binding motif, and its transport activity is not Ca++ dependent (1).

In yeast, mutations in AGC1 result in decreased synthesis of valine, ornithine and citrulline, and the inability to grow on acetate or oleic acid. In humans, mutations in SLC25A13 are associated with type II citrullinemia (both adult-onset (OMIM) and neonatal-onset (OMIM1 and references therein).

Last updated: 2007-06-21

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for AGC1]

1) Cavero S, et al.  (2003) Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae. Mol Microbiol 50(4):1257-69
2) Belenkiy R, et al.  (2000) The yeast mitochondrial transport proteins: new sequences and consensus residues, lack of direct relation between consensus residues and transmembrane helices, expression patterns of the transport protein genes, and protein-protein interactions with other proteins. Biochim Biophys Acta 1467(1):207-18