AGC1/YPR021C Summary Help

Standard Name AGC1 1
Systematic Name YPR021C
Feature Type ORF, Verified
Description Mitochondrial amino acid transporter; acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis (1 and see Summary Paragraph)
Name Description Aspartate-Glutamate Carrier 1
Chromosomal Location
ChrXVI:603357 to 600649 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All AGC1 GO evidence and references
  View Computational GO annotations for AGC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
15 total interaction(s) for 13 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • PCA: 2

Genetic Interactions
  • Negative Genetic: 5
  • Synthetic Growth Defect: 5
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 902
Molecular Weight (Da) 104,303
Isoelectric Point (pI) 8.08
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:603357 to 600649 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2709 603357..600649 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000006225
SUMMARY PARAGRAPH for AGC1

AGC1 encodes a mitochondrial inner membrane aspartate/glutamate transporter that contributes to the biosynthesis of nitrogen compounds (1, 2). Agc1p is orthologous to the human proteins aralar (encoded by SLC25A12 (OMIM)) and citrin (encoded by SLC25A13 (OMIM)). Like the human orthologs, Agc1p can act as an aspartate-glutamate antiporter. In contrast to the human orthologs, Agc1p also functions as a uniporter for both glutamate and aspartate, it does not contain an N-terminal EF-hand Ca++-binding motif, and its transport activity is not Ca++ dependent (1).

In yeast, mutations in AGC1 result in decreased synthesis of valine, ornithine and citrulline, and the inability to grow on acetate or oleic acid. In humans, mutations in SLC25A13 are associated with type II citrullinemia (both adult-onset (OMIM) and neonatal-onset (OMIM1 and references therein).

Last updated: 2007-06-21 Contact SGD

References cited on this page View Complete Literature Guide for AGC1
1) Cavero S, et al.  (2003) Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae. Mol Microbiol 50(4):1257-69
2) Belenkiy R, et al.  (2000) The yeast mitochondrial transport proteins: new sequences and consensus residues, lack of direct relation between consensus residues and transmembrane helices, expression patterns of the transport protein genes, and protein-protein interactions with other proteins. Biochim Biophys Acta 1467(1):207-18