AFT2/YPL202C Summary Help

Standard Name AFT2 1
Systematic Name YPL202C
Feature Type ORF, Verified
Description Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Activator of Fe (iron) Transcription 1
Chromosomal Location
ChrXVI:169338 to 168088 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All AFT2 GO evidence and references
  View Computational GO annotations for AFT2
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Targets 81 genes
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
35 total interaction(s) for 25 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Reconstituted Complex: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 17
  • Phenotypic Enhancement: 3
  • Positive Genetic: 2
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 416
Molecular Weight (Da) 47,104
Isoelectric Point (pI) 9.15
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:169338 to 168088 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1251 169338..168088 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006123
References cited on this page View Complete Literature Guide for AFT2
1) Blaiseau PL, et al.  (2001) Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast. J Biol Chem 276(36):34221-6
2) Rutherford JC, et al.  (2001) A second iron-regulatory system in yeast independent of Aft1p. Proc Natl Acad Sci U S A 98(25):14322-7
3) Courel M, et al.  (2005) Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1. Mol Cell Biol 25(15):6760-71
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87
6) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104