AFT2/YPL202C Summary

AFT2 BASIC INFORMATION

Standard Name	AFT2 1
Systematic Name	YPL202C
Feature Type	ORF, Verified
Description	Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; similar to Aft1p (1, 2, 3)
Name Description	Activator of Fe (iron) Transcription 1

GO Annotations	All AFT2 GO evidence and references
	View Computational GO annotations for AFT2
Molecular Function
Manually curated	specific RNA polymerase II transcription factor activity (IMP, ISS) transcription factor activity (IDA)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	cellular iron ion homeostasis (IMP, ISS) positive regulation of transcription (IDA) response to oxidative stress (IMP, ISS) transcription initiation from RNA polymerase II promoter (IMP, ISS)
Cellular Component
Manually curated	nucleus (IMP, ISS)
High-throughput	mitochondrion (IDA)

Regulatory Role
Binding motifs	AFT2 Transcription Factor Binding Sites and References
	RCACCC YRCACCCR

Mutant Phenotype	All AFT2 Phenotype details and references
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to methanol: decreased viable

Interactions	AFT2 All interactions details and references
	9 total interaction(s) for 4 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 3 Synthetic Growth Defect: 3 Synthetic Lethality: 1

Sequence Information

ChrXVI:169337 to 168087 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1251	169337..168087	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006123

AFT2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for AFT2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for AFT2]

1)	Blaiseau PL, et al. (2001) Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast. J Biol Chem 276(36):34221-6
2)	Rutherford JC, et al. (2001) A second iron-regulatory system in yeast independent of Aft1p. Proc Natl Acad Sci U S A 98(25):14322-7
3)	Courel M, et al. (2005) Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1. Mol Cell Biol 25(15):6760-71

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