Standard Name	AFR1
Systematic Name	YDR085C
Feature Type	ORF, Verified
Description	Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6)
Name Description	Alpha-Factor Receptor regulator 7

Chromosomal Location	ChrIV:616150 to 614288 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 47.97 cM

Molecular Function
Manually curated	receptor signaling protein activity (IMP, IPI)
Biological Process
Manually curated	cell morphogenesis involved in conjugation (IMP) cell morphogenesis involved in conjugation with cellular fusion (IMP) pheromone-dependent signal transduction involved in conjugation with cellular fusion (IGI, IMP, IPI) regulation of G-protein coupled receptor protein signaling pathway (IMP, IPI)
Cellular Component
Manually curated	mating projection base (IDA)

Regulatory modules	predicted: stressResponse (607, 481, 457, 451)

Classical genetics
null	Cdc10p distribution: abnormal Cdc12p distribution: abnormal Glc7p distribution: abnormal shmoo formation: abnormal
reduction of function	shmoo formation: abnormal
Large-scale survey
null	budding index: increased competitive fitness: increased resistance to benzo[a]pyrene: increased resistance to benzo[a]pyrene: decreased resistance to L-1,4-dithiothreitol: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	24 total interaction(s) for 18 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 FRET: 2 Protein-RNA: 1 Two-hybrid: 9
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 1 Negative Genetic: 2 Positive Genetic: 1 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:616150 to 614288 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 47.97 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1863 616150..614288 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002492