AFG2/YLR397C Summary Help

AFG2 BASIC INFORMATION

Standard Name AFG2
Systematic Name YLR397C
Alias DRG1
Feature Type ORF, Verified
Description ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; may be involved in degradation of aberrant mRNAs (1, 2, 3)
Name Description ATPase Family Gene 1
GO Annotations All AFG2 GO evidence and references
    View Computational GO annotations for AFG2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All AFG2 Phenotype details and references
Classical genetics
conditional
null
reduction of function
Large-scale survey
null
Interactions AFG2 All interactions details and references
10 total interaction(s) for 10 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-Western: 2
  • Biochemical Activity: 2
  • PCA: 1
  • Two-hybrid: 2
Sequence Information
ChrXII:914892 to 912550 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-02-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2343 914892..912550 2004-02-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004389

AFG2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for AFG2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for AFG2]

1) Thorsness PE, et al.  (1993) AFG2, an essential gene in yeast, encodes a new member of the Sec18p, Pas1p, Cdc48p, TBP-1 family of putative ATPases. Yeast 9(11):1267-71
2) Zakalskiy A, et al.  (2002) Structural and enzymatic properties of the AAA protein Drg1p from Saccharomyces cerevisiae. Decoupling of intracellular function from ATPase activity and hexamerization. J Biol Chem 277(30):26788-95
3) Pertschy B, et al.  (2007) Cytoplasmic Recycling of 60S Preribosomal Factors Depends on the AAA Protein Drg1. Mol Cell Biol 27(19):6581-92