AFG1/YEL052W Summary

AFG1 BASIC INFORMATION

Standard Name	AFG1
Systematic Name	YEL052W
Feature Type	ORF, Verified
Description	Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain (1, 2, 3)
Name Description	ATPase Family Gene 1

GO Annotations	All AFG1 GO evidence and references
	View Computational GO annotations for AFG1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	misfolded or incompletely synthesized protein catabolic process (IMP) protein import into peroxisome matrix (IMP) response to oxidative stress (IMP)
Cellular Component
Manually curated	mitochondrial inner membrane (IDA)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All AFG1 Phenotype details and references
Classical genetics
null	Mdh3p-GFP distribution: abnormal Pot1p-GFP distribution: abnormal Pex14p-GFP distribution: normal respiratory growth: decreased rate
Large-scale survey
null	GFP-PTS1 distribution: abnormal respiratory growth: decreased rate viable

Interactions	AFG1 All interactions details and references
	4 total interaction(s) for 4 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1
Genetic Interactions	Dosage Rescue: 2 Synthetic Lethality: 1

Sequence Information

ChrV:56571 to 58100 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1530	56571..58100	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000778

AFG1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for AFG1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for AFG1]

1)	Lee YJ and Wickner RB (1992) AFG1, a new member of the SEC18-NSF, PAS1, CDC48-VCP, TBP family of ATPases. Yeast 8(9):787-90
2)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3)	Khalimonchuk O, et al. (2007) Evidence for a pro-oxidant intermediate in the assembly of cytochrome oxidase. J Biol Chem 282(24):17442-9

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