ADO1/YJR105W Summary

ADO1 BASIC INFORMATION

Standard Name	ADO1 1
Systematic Name	YJR105W
Feature Type	ORF, Verified
Description	Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle (1)
Name Description	ADenOsine kinase 1

GO Annotations	All ADO1 GO evidence and references
	View Computational GO annotations for ADO1
Molecular Function
Manually curated	adenosine kinase activity (IDA, IMP)
Biological Process
Manually curated	purine base metabolic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	salvage pathways of adenine, hypoxanthine, and their nucleosides salvage pathways of purines and their nucleosides superpathway of purine biosynthesis and salvage pathways

Mutant Phenotype	All ADO1 Phenotype details and references
Classical genetics
null	resistance to cordycepin: increased
Large-scale survey
null	glycogen accumulation: increased competitive fitness: decreased fermentative growth: decreased rate resistance to ethanol: decreased resistance to hygromycin B: decreased resistance to oleate: decreased resistance to hydroxyurea: increased resistance to L-1,4-dithiothreitol: decreased resistance to tunicamycin: decreased telomere length: decreased toxin resistance: increased utilization of phosphorus source: decreased viable
overexpression	filamentous growth: increased

Interactions	ADO1 All interactions details and references
	104 total interaction(s) for 100 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Biochemical Activity: 4
Genetic Interactions	Phenotypic Enhancement: 41 Phenotypic Suppression: 39 Synthetic Growth Defect: 2 Synthetic Lethality: 6

Sequence Information

ChrX:623569 to 624591 | |

Last Update

Coordinates: 2009-02-18 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1023	623569..624591	2009-02-18	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003866

ADO1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ADO1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ADO1]

1)	Lecoq K, et al. (2001) Role of adenosine kinase in Saccharomyces cerevisiae: identification of the ADO1 gene and study of the mutant phenotypes. Yeast 18(4):335-42

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.