ADK2/YER170W Summary

ADK2 BASIC INFORMATION

Standard Name	ADK2 1
Systematic Name	YER170W
Alias	AKY3 2 , PAK3 2
Feature Type	ORF, Verified
Description	Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background (3)
Name Description	ADenylate Kinase 1

GO Annotations	All ADK2 GO evidence and references
	View Computational GO annotations for ADK2
Molecular Function
Manually curated	adenylate kinase activity (IDA) nucleoside triphosphate adenylate kinase activity (IDA)
Biological Process
Manually curated	nucleotide metabolic process (IDA)
Cellular Component
Manually curated	mitochondrial inner membrane (IDA)
High-throughput	mitochondrion (IDA)

Pathways	de novo biosynthesis of purine nucleotides superpathway of histidine, purine, and pyrimidine biosynthesis superpathway of purine biosynthesis and salvage pathways

Mutant Phenotype	All ADK2 Phenotype details and references
Large-scale survey
null	viable

Interactions	ADK2 All interactions details and references
	7 total interaction(s) for 7 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 PCA: 1
Genetic Interactions	Phenotypic Suppression: 5

Sequence Information

ChrV:525969 to 526646 | |

Genetic position: 146 cM

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..678	525969..526646	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000972

ADK2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ADK2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ADK2]

1)	Cooper AJ and Friedberg EC (1992) A putative second adenylate kinase-encoding gene from the yeast Saccharomyces cerevisiae. Gene 114(1):145-8
2)	Schricker R, et al. (1995) Strain-dependent occurrence of functional GTP:AMP phosphotransferase (AK3) in Saccharomyces cerevisiae. J Biol Chem 270(52):31103-10
3)	Gu Y, et al. (2005) A GTP:AMP phosphotransferase, Adk2p, in Saccharomyces cerevisiae. Role of the C terminus in protein folding/stabilization, thermal tolerance, and enzymatic activity. J Biol Chem 280(19):18604-9

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