Standard Name	ADK1 1
Systematic Name	YDR226W
Alias	AKY1 , AKY2 2 , 3
Feature Type	ORF, Verified
Description	Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress (1, 4, 5, 6)
Name Description	ADenylate Kinase 1

Chromosomal Location	ChrIV:916486 to 917154 | ORF Map | GBrowse
	Genetic position: 133 cM

	View Computational GO annotations for ADK1
Molecular Function
Manually curated	adenylate kinase activity (IDA, IMP)
Biological Process
Manually curated	ADP biosynthetic process (IDA) DNA replication initiation (IMP) nucleotide metabolic process (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) mitochondrial intermembrane space (IDA)
High-throughput	mitochondrion (IDA)

Pathways	de novo biosynthesis of purine nucleotides superpathway of histidine, purine, and pyrimidine biosynthesis superpathway of purine biosynthesis and salvage pathways

Classical genetics
null	IMP accumulation: increased inosine accumulation: increased ADP accumulation: decreased ATP accumulation: decreased hypoxanthine accumulation: increased AMP accumulation: increased ethanol accumulation: increased glycerol accumulation: increased chromosome/plasmid maintenance: abnormal growth in exponential phase: decreased rate metal resistance: decreased respiratory metabolism: increased utilization of carbon source: absent utilization of carbon source: increased vegetative growth: decreased viability: decreased viable
Large-scale survey
null	auxotrophy bud morphology: abnormal cell cycle progression in G1 phase: increased duration cell size: increased glycogen accumulation: increased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased heat sensitivity: increased inviable lipid particle morphology: abnormal metal resistance: decreased resistance to doxorubicin: decreased resistance to hydroxyurea: increased resistance to tunicamycin: decreased resistance to caffeine: decreased resistance to sulfanilamide: decreased resistance to pentachlorophenol: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to L-1,4-dithiothreitol: decreased respiratory growth: absent toxin resistance: decreased utilization of phosphorus source: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	73 total interaction(s) for 68 unique genes/features.
Physical Interactions	Affinity Capture-MS: 17 Affinity Capture-RNA: 4 Affinity Capture-Western: 2 Biochemical Activity: 7 PCA: 3 Protein-peptide: 3
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 23 Phenotypic Suppression: 1 Positive Genetic: 10 Synthetic Growth Defect: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:916486 to 917154 | ORF Map | GBrowse
	Genetic position: 133 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..669 916486..917154 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002634