ADI1/YMR009W Summary

ADI1 BASIC INFORMATION

Standard Name	ADI1 1
Systematic Name	YMR009W
Feature Type	ORF, Verified
Description	Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions (1, 2)
Name Description	Acireductone DIoxygenase 1

GO Annotations	All ADI1 GO evidence and references
	View Computational GO annotations for ADI1
Molecular Function
Manually curated	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (IGI, IMP, ISS)
Biological Process
Manually curated	L-methionine salvage from methylthioadenosine (IGI, IMP, ISS)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	methionine salvage pathway superpathway of methionine salvage pathway

Mutant Phenotype	All ADI1 Phenotype details and references
Classical genetics
null	5'-S-methyl-5'-thioadenosine accumulation: increased nutrient utilization: abnormal
Large-scale survey
null	UV resistance: decreased viable

Interactions	ADI1 All interactions details and references
	2 total interaction(s) for 2 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Two-hybrid: 1

Sequence Information

ChrXIII:284101 to 284640 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..540	284101..284640	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004611

ADI1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for ADI1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ADI1]

1)	Zer C and Chanfreau G (2005) Regulation and surveillance of normal and 3'-extended forms of the yeast aci-reductone dioxygenase mRNA by RNase III cleavage and exonucleolytic degradation. J Biol Chem 280(32):28997-9003
2)	Hirano W, et al. (2005) Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway. Genes Cells 10(6):565-74

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