ADI1/YMR009W Summary Help

Standard Name ADI1 1
Systematic Name YMR009W
Feature Type ORF, Verified
Description Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions (1, 2)
Name Description Acireductone DIoxygenase 1
Chromosomal Location
ChrXIII:284102 to 284641 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ADI1 GO evidence and references
  View Computational GO annotations for ADI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 11 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
Resources
47 total interaction(s) for 40 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 3
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 30
  • Positive Genetic: 10
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 179
Molecular Weight (Da) 20,879
Isoelectric Point (pI) 5.08
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:284102 to 284641 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..540 284102..284641 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004611
References cited on this page View Complete Literature Guide for ADI1
1) Zer C and Chanfreau G  (2005) Regulation and surveillance of normal and 3'-extended forms of the yeast aci-reductone dioxygenase mRNA by RNase III cleavage and exonucleolytic degradation. J Biol Chem 280(32):28997-9003
2) Hirano W, et al.  (2005) Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway. Genes Cells 10(6):565-74