ADE8/YDR408C Summary

ADE8 BASIC INFORMATION

Standard Name	ADE8
Systematic Name	YDR408C
Feature Type	ORF, Verified
Description	Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway (1)
Name Description	ADEnine requiring

GO Annotations	All ADE8 GO evidence and references
	View Computational GO annotations for ADE8
Molecular Function
Manually curated	phosphoribosylglycinamide formyltransferase activity (TAS)
Biological Process
Manually curated	'de novo' IMP biosynthetic process (TAS) adenine biosynthetic process (TAS) purine nucleotide biosynthetic process (TAS)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	de novo biosynthesis of purine nucleotides superpathway of histidine, purine, and pyrimidine biosynthesis superpathway of purine biosynthesis and salvage pathways

Mutant Phenotype	All ADE8 Phenotype details and references
Classical genetics
null	auxotrophy
Large-scale survey
null	competitive fitness: decreased lipid particle morphology: abnormal viable

Interactions	ADE8 All interactions details and references
	7 total interaction(s) for 7 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Two-hybrid: 3
Genetic Interactions	Phenotypic Suppression: 1

Sequence Information

ChrIV:1288852 to 1288208 | |

Note: this feature is encoded on the Crick strand.

Genetic position: 256 cM

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..645	1288852..1288208	2008-06-05	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002816

ADE8 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ADE8

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ADE8]

1)	Jones EW and Fink GR (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.