ADE5,7/YGL234W Summary

ADE5,7 BASIC INFORMATION

Standard Name	ADE5,7
Systematic Name	YGL234W
Feature Type	ORF, Verified
Description	Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities (1)
Name Description	ADEnine requiring

GO Annotations	All ADE5,7 GO evidence and references
	View Computational GO annotations for ADE5,7
Molecular Function
Manually curated	phosphoribosylamine-glycine ligase activity (TAS) phosphoribosylformylglycinamidine cyclo-ligase activity (TAS)
Biological Process
Manually curated	'de novo' IMP biosynthetic process (TAS) purine base metabolic process (TAS) purine nucleotide biosynthetic process (TAS)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	de novo biosynthesis of purine nucleotides superpathway of histidine, purine, and pyrimidine biosynthesis superpathway of purine biosynthesis and salvage pathways

Mutant Phenotype	All ADE5,7 Phenotype details and references
Classical genetics
null	auxotrophy
Large-scale survey
null	competitive fitness: decreased viable

Interactions	ADE5,7 All interactions details and references
	19 total interaction(s) for 18 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Biochemical Activity: 2 Two-hybrid: 1
Genetic Interactions	Phenotypic Suppression: 1 Synthetic Growth Defect: 2

Sequence Information

ChrVII:56482 to 58890 | |

Genetic position: -152 cM

Last Update

Coordinates: 2004-07-15 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2409	56482..58890	2004-07-15	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003203

ADE5,7 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ADE5,7

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ADE5,7]

1)	Jones EW and Fink GR (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press

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