ADE3/YGR204W Summary Help

ADE3 BASIC INFORMATION

Standard Name ADE3
Systematic Name YGR204W
Feature Type ORF, Verified
Description Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine (1, 2, 3)
Name Description ADEnine requiring
GO Annotations All ADE3 GO evidence and references
    View Computational GO annotations for ADE3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Pathways
Mutant Phenotype All ADE3 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions ADE3 All interactions details and references
28 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 15
  • Affinity Capture-RNA: 1
  • Co-purification: 1
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 2
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 7
Sequence Information
ChrVII:905939 to 908779 | ORF Map | GBrowse
Gbrowse
Genetic position: 159 cM
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2841 905939..908779 2004-07-20 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003436

ADE3 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for ADE3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ADE3]

1) Song JM and Rabinowitz JC  (1993) Function of yeast cytoplasmic C1-tetrahydrofolate synthase. Proc Natl Acad Sci U S A 90(7):2636-40
2) McKenzie KQ and Jones EW  (1977) Mutants of formyltetrahydrofolate interconversion pathway of Saccharomyces cerevisiae. Genetics 86(1):85-102
3) Jones EW and Fink GR  (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press