ADE16/YLR028C Summary

ADE16 BASIC INFORMATION

Standard Name	ADE16
Systematic Name	YLR028C
Feature Type	ORF, Verified
Description	Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine (1)
Name Description	ADEnine requiring

GO Annotations	All ADE16 GO evidence and references
	View Computational GO annotations for ADE16
Molecular Function
Manually curated	IMP cyclohydrolase activity (IDA) phosphoribosylaminoimidazolecarboxamide formyltransferase activity (IDA)
Biological Process
Manually curated	'de novo' IMP biosynthetic process (IDA, IMP) aerobic respiration (IEP) ascospore formation (IEP) purine nucleotide biosynthetic process (IDA, IMP)
Cellular Component
Manually curated	cytosol (IDA)

Pathways	de novo biosynthesis of purine nucleotides superpathway of histidine, purine, and pyrimidine biosynthesis superpathway of purine biosynthesis and salvage pathways

Mutant Phenotype	All ADE16 Phenotype details and references
Classical genetics
null	resistance to cisplatin: increased
Large-scale survey
null	sporulation: abnormal viable

Interactions	ADE16 All interactions details and references
	33 total interaction(s) for 21 unique genes/features.
Physical Interactions	Affinity Capture-MS: 19 Affinity Capture-RNA: 1 PCA: 6
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 3 Phenotypic Enhancement: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 1

Sequence Information

ChrXII:201316 to 199541 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1997-07-30 | Sequence: 1997-07-30

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1776	201316..199541	1997-07-30	1997-07-30

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004018

ADE16 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ADE16

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ADE16]

1)	Tibbetts AS and Appling DR (2000) Characterization of two 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase isozymes from Saccharomyces cerevisiae. J Biol Chem 275(27):20920-7

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