Standard Name	ADD66 1
Systematic Name	YKL206C
Alias	PBA2 2 , POC2 3
Feature Type	ORF, Verified
Description	Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly (2, 4)
Name Description	Alpha1-proteinase inhibitor-Degradation Deficient 1

Chromosomal Location	ChrXI:49809 to 49006 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for ADD66
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	proteasome assembly (IGI, IMP, ISS)
Cellular Component
Manually curated	cytosol (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	metal resistance: decreased resistance to methyl methanesulfonate: increased resistance to 4-nitroquinoline N-oxide: increased resistance to canavanine: normal resistance to camptothecin: increased
Large-scale survey
null	resistance to elesclomol-Cu: decreased resistance to ethanol: decreased stress resistance: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	45 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 3 Affinity Capture-Western: 3 Biochemical Activity: 3 Co-crystal Structure: 1 Co-fractionation: 2 Reconstituted Complex: 1
Genetic Interactions	Negative Genetic: 6 Positive Genetic: 9 Synthetic Growth Defect: 7 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:49809 to 49006 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..804 49809..49006 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001689