ADD37/YMR184W Summary Help

Standard Name ADD37 1
Systematic Name YMR184W
Feature Type ORF, Verified
Description Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5)
Name Description Alpha1-proteinase inhibitor-Degradation Deficient 1
Chromosomal Location
ChrXIII:628189 to 628785 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ADD37 GO evidence and references
  View Computational GO annotations for ADD37
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 10 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
23 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 4
  • Biochemical Activity: 18

Genetic Interactions
  • Dosage Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 198
Molecular Weight (Da) 22,109
Isoelectric Point (pI) 9.06
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:628189 to 628785 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..597 628189..628785 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004796
References cited on this page View Complete Literature Guide for ADD37
1) Palmer EA, et al.  (2003) Differential requirements of novel A1PiZ degradation deficient (ADD) genes in ER-associated protein degradation. J Cell Sci 116(Pt 11):2361-73
2) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Lee MW, et al.  (2007) Global protein expression profiling of budding yeast in response to DNA damage. Yeast 24(3):145-54
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76