ACS2/YLR153C Summary Help

Standard Name ACS2 1
Systematic Name YLR153C
Feature Type ORF, Verified
Description Acetyl-coA synthetase isoform; along with Acs1p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions (2, 3, 4)
Name Description Acetyl CoA Synthetase 5
Chromosomal Location
ChrXII:447575 to 445524 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ACS2 GO evidence and references
  View Computational GO annotations for ACS2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 130 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
overexpression
reduction of function
repressible
Resources
221 total interaction(s) for 184 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 46
  • Affinity Capture-RNA: 1
  • PCA: 2
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 45
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 7
  • Synthetic Growth Defect: 66
  • Synthetic Lethality: 39
  • Synthetic Rescue: 11

Resources
Expression Summary
histogram
Resources
Length (a.a.) 683
Molecular Weight (Da) 75,491
Isoelectric Point (pI) 6.67
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:447575 to 445524 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2052 447575..445524 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004143
References cited on this page View Complete Literature Guide for ACS2
1) Van den Berg MA and Steensma HY  (1995) ACS2, a Saccharomyces cerevisiae gene encoding acetyl-coenzyme A synthetase, essential for growth on glucose. Eur J Biochem 231(3):704-13
2) van den Berg MA, et al.  (1996) The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation. J Biol Chem 271(46):28953-9
3) Guranowski A, et al.  (1994) Adenosine 5'-tetraphosphate and adenosine 5'-pentaphosphate are synthesized by yeast acetyl coenzyme A synthetase. J Bacteriol 176(10):2986-90
4) Takahashi H, et al.  (2006) Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol Cell 23(2):207-17
5) De Virgilio C, et al.  (1992) Cloning and disruption of a gene required for growth on acetate but not on ethanol: the acetyl-coenzyme A synthetase gene of Saccharomyces cerevisiae. Yeast 8(12):1043-51