ACS2/YLR153C Summary

ACS2 BASIC INFORMATION

Standard Name	ACS2
Systematic Name	YLR153C
Feature Type	ORF, Verified
Description	Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions (1, 2, 3)
Name Description	Acetyl CoA Synthetase

GO Annotations	All ACS2 GO evidence and references
	View Computational GO annotations for ACS2
Molecular Function
Manually curated	acetate-CoA ligase activity (IDA)
Biological Process
Manually curated	acetyl-CoA biosynthetic process (IDA) histone acetylation (IMP) replicative cell aging (IMP)
Cellular Component
Manually curated	cytosol (IDA) nucleolus (IDA) nucleus (IDA)

Pathways	acetate utilization

Mutant Phenotype	All ACS2 Phenotype details and references
Classical genetics
null	growth in exponential phase: decreased rate replicative lifespan: decreased resistance to phleomycin: increased silencing: decreased utilization of carbon source: decreased
Large-scale survey
null	inviable
overexpression	resistance to rapamycin: increased

Interactions	ACS2 All interactions details and references
	149 total interaction(s) for 130 unique genes/features.
Physical Interactions	Affinity Capture-MS: 31 Two-hybrid: 2
Genetic Interactions	Phenotypic Enhancement: 1 Synthetic Growth Defect: 53 Synthetic Lethality: 52 Synthetic Rescue: 10

Sequence Information

ChrXII:447576 to 445525 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2052	447576..445525	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004143

ACS2 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for ACS2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ACS2]

1)	van den Berg MA, et al. (1996) The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation. J Biol Chem 271(46):28953-9
2)	Guranowski A, et al. (1994) Adenosine 5'-tetraphosphate and adenosine 5'-pentaphosphate are synthesized by yeast acetyl coenzyme A synthetase. J Bacteriol 176(10):2986-90
3)	Takahashi H, et al. (2006) Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol Cell 23(2):207-17

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