SDH7/YDR511W Summary Help

Standard Name SDH7 1
Systematic Name YDR511W
Alias ACN9 2
Feature Type ORF, Verified
Description Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; localized to the mitochondrial intermembrane space; required for acetate utilization and gluconeogenesis; mutation in Drosophila ortholog SDHAF3 causes reduced succinate dehydrogenase activity and neuronal and muscular dysfunction; member of the LYR protein family (1, 2, 3, 4)
Name Description Succinate DeHydrogenase 1
Chromosomal Location
ChrIV:1470017 to 1470418 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SDH7 GO evidence and references
  View Computational GO annotations for SDH7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
Resources
21 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Co-purification: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 14
  • Positive Genetic: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 133
Molecular Weight (Da) 15,783
Isoelectric Point (pI) 9.96
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1470017 to 1470418 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..402 1470017..1470418 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002919
References cited on this page View Complete Literature Guide for SDH7
1) Na U, et al.  (2014) The LYR Factors SDHAF1 and SDHAF3 Mediate Maturation of the Iron-Sulfur Subunit of Succinate Dehydrogenase. Cell Metab ()
2) McCammon MT  (1996) Mutants of Saccharomyces cerevisiae with defects in acetate metabolism: isolation and characterization of Acn- mutants. Genetics 144(1):57-69
3) Dennis RA, et al.  (1999) Yeast mutants of glucose metabolism with defects in the coordinate regulation of carbon assimilation. Arch Biochem Biophys 365(2):279-88
4) Dennis RA and McCammon MT  (1999) Acn9 is a novel protein of gluconeogenesis that is located in the mitochondrial intermembrane space. Eur J Biochem 261(1):236-43