Standard Name	ACK1 1
Systematic Name	YDL203C
Feature Type	ORF, Verified
Description	Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria (1, 2, 3, 4)
Name Description	Activator of C Kinase 1 1

Chromosomal Location	ChrIV:97953 to 96082 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	fungal-type cell wall organization (IMP) positive regulation of signal transduction (IMP)
Cellular Component
High-throughput	mitochondrion (IDA)

Classical genetics
null	resistance to staurosporine: decreased resistance to tunicamycin: decreased
overexpression	budding: abnormal cell cycle progression in G2 phase: abnormal cellular morphology: abnormal
Large-scale survey
null	auxotrophy competitive fitness: increased competitive fitness: decreased haploinsufficient resistance to streptomycin: decreased resistance to cycloheximide: decreased resistance to tunicamycin: decreased resistance to 1,4-dithiothreitol: decreased stress resistance: decreased viable
overexpression	vegetative growth: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	78 total interaction(s) for 53 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-Western: 2 Biochemical Activity: 4 Co-localization: 1 PCA: 1 Protein-peptide: 1 Reconstituted Complex: 5 Two-hybrid: 5
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 30 Phenotypic Enhancement: 2 Phenotypic Suppression: 9 Positive Genetic: 1 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:97953 to 96082 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1872 97953..96082 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002362