ACE2/YLR131C Summary Help

ACE2 BASIC INFORMATION

Standard Name ACE2 1
Systematic Name YLR131C
Feature Type ORF, Verified
Description Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate (2, 3, 4, 5 and see Summary Paragraph)
Name Description Activator of CUP1 Expression 1
GO Annotations All ACE2 GO evidence and references
    View Computational GO annotations for ACE2
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Binding motifs ACE2 Transcription Factor Binding Sites and References
  • GCTGGT
  • TGCTGGT
Mutant Phenotype All ACE2 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions ACE2 All interactions details and references
53 total interaction(s) for 37 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-Western: 3
  • Biochemical Activity: 5
  • Protein-peptide: 1
  • Protein-RNA: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 10
Genetic Interactions
  • Dosage Rescue: 6
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 6
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1
Sequence Information
ChrXII:406823 to 404511 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2313 406823..404511 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004121

ACE2 RESOURCES

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SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for ACE2

SUMMARY PARAGRAPH for ACE2

ACE2 encodes a transcription factor that activates transcription of genes expressed in the G1 phase of the cell cycle (3, 6, 7). The DNA binding domain of Ace2p is very similar to that of another G1 specifc transcription activator, Swi5p (3). Swi5p and Ace2p bind the same DNA sequences in vitro with similar affinites, and regulate a shared set of genes in vivo(6, 7); however, the two proteins also show distinct promoter specificities in some instances (3, 7). Ace2p activates transcription of CTS1, which encodes endochitinase, whereas Swi5p does not; conversely, HO is activated by Swi5p and not by Ace2p (3). Distinct regions of Ace2p and Swi5p that are involved in promoter-specific transcription activation have been identified (7).

ACE2 is transcribed in G2 phase (3); cell cycle specific ACE2 expression requires Mcm1p and the uncloned "Swi Five Factor (SFF)" (8, 9). The localization of Ace2p is regulated by phosphorylation; dephosphorylated Ace2p is found in the nucleus, and therefore active, in late M and early G1 phases (2).

Last updated: 1999-12-03

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ACE2]

1) Butler G and Thiele DJ  (1991) ACE2, an activator of yeast metallothionein expression which is homologous to SWI5. Mol Cell Biol 11(1):476-85
2) O'Conallain C, et al.  (1999) Regulated nuclear localisation of the yeast transcription factor Ace2p controls expression of chitinase (CTS1) in Saccharomyces cerevisiae. Mol Gen Genet 262(2):275-82
3) Dohrmann PR, et al.  (1992) Parallel pathways of gene regulation: homologous regulators SWI5 and ACE2 differentially control transcription of HO and chitinase. Genes Dev 6(1):93-104
4) Laabs TL, et al.  (2003) ACE2 is required for daughter cell-specific G1 delay in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 100(18):10275-80
5) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
6) Dohrmann PR, et al.  (1996) Role of negative regulation in promoter specificity of the homologous transcriptional activators Ace2p and Swi5p. Mol Cell Biol 16(4):1746-58
7) McBride HJ, et al.  (1999) Distinct regions of the Swi5 and Ace2 transcription factors are required for specific gene activation. J Biol Chem 274(30):21029-36
8) Lydall D, et al.  (1991) A new role for MCM1 in yeast: cell cycle regulation of SW15 transcription. Genes Dev 5(12B):2405-19
9) Althoefer H, et al.  (1995) Mcm1 is required to coordinate G2-specific transcription in Saccharomyces cerevisiae. Mol Cell Biol 15(11):5917-28