| Standard Name | ACB1 1, 2, 3 |
|---|---|
| Systematic Name | YGR037C |
| Feature Type | ORF, Verified |
| Description | Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress (4, 5, 6, 7) |
| Name Description | Acyl-CoA-Binding 1, 5 |
| Chromosomal Location | |
|---|---|
| Note: this feature is encoded on the Crick strand. | |
Gene Ontology Annotations All ACB1 GO evidence and references
| View Computational GO annotations for ACB1 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated | |
| High-throughput |
Mutant phenotypes All ACB1 Phenotype evidence and references
| Classical genetics | |
|---|---|
| null | |
| Large-scale survey | |
| null |
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| Resources |
interactions All ACB1 Interaction evidence and references
| 65 total interaction(s) for 64 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All ACB1 Protein evidence and references
| Localization | |
|---|---|
| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
| Note: this feature is encoded on the Crick strand. | |||||||||||||
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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Analyze Sequence
| S288C only | |
|---|---|
| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000003269 |
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References cited on this page View Complete Literature Guide for ACB1
| 1) | Borsting C, et al. (1997) Saccharomyces carlsbergensis contains two functional genes encoding the acyl-CoA binding protein, one similar to the ACB1 gene from S. cerevisiae and one identical to the ACB1 gene from S. monacensis. Yeast 13(15):1409-21 |
| 2) | Mueller, L., et al. (1996) RanBP3 is a nuclear Ran-GTP binding protein that forms a Ran-dependent complex with RCC1 in vivo and in vitro. Unpublished |
| 3) | Rose, T.M. (1994) Personal Communication, Mortimer Map Edition 12 |
| 4) | Schjerling CK, et al. (1996) Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae. J Biol Chem 271(37):22514-21 |
| 5) | Rose TM, et al. (1992) Molecular cloning of the gene for the yeast homolog (ACB) of diazepam binding inhibitor/endozepine/acyl-CoA-binding protein. Proc Natl Acad Sci U S A 89(23):11287-91 |
| 6) | Duran JM, et al. (2010) Unconventional secretion of Acb1 is mediated by autophagosomes. J Cell Biol 188(4):527-36 |
| 7) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |





