ABZ1/YNR033W Summary Help

ABZ1 BASIC INFORMATION

Standard Name ABZ1
Systematic Name YNR033W
Feature Type ORF, Verified
Description Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB (1, 2 and see Summary Paragraph)
Name Description para-AminoBenZoic acid (PABA) biosynthesis
GO Annotations All ABZ1 GO evidence and references
    View Computational GO annotations for ABZ1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Pathways
Mutant Phenotype All ABZ1 Phenotype details and references
Large-scale survey
null
Interactions ABZ1 All interactions details and references
5 total interaction(s) for 5 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Biochemical Activity: 3
  • Two-hybrid: 1
Sequence Information
ChrXIV:687638 to 690001 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2010-01-05 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2364 687638..690001 2010-01-05 1997-01-28
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005316

ABZ1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for ABZ1

SUMMARY PARAGRAPH for ABZ1

ABZ1 encodes a cytoplasmic protein (3) required for synthesis of para-aminobenzoic acid (PABA), an important component in folic acid synthesis (1, 2). Specifically, Abz1p is aminodeoxychorismate synthase (E.C. 6.3.5.8), which converts chorismate to 4-amino-4-deoxychorismate. ABZ1p resembles a fusion of the E. coli proteins pabA and pabB, which together form a complex that performs the same reaction (1). In E. coli, a third enzyme, pabC (E.C. 4.1.3.38), converts aminodeoxychorismate to PABA. Deletion of ABZ1 causes PABA auxotrophy, but mutants cultured in PABA-supplemented medium grow normally (1).

Sulfa drugs, which are often used to treat AIDS patients with opportunistic microbial infections, compete with PABA in the folic acid synthesis pathway (2). Overexpression of ABZ1 confers sulfa resistance in Saccharomyces cerevisiae (1, 2).

Last updated: 2005-08-25

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ABZ1]

1) Edman JC, et al.  (1993) Para-aminobenzoate synthase gene of Saccharomyces cerevisiae encodes a bifunctional enzyme. Yeast 9(6):669-75
2) Castelli LA, et al.  (2001) Sulfa drug screening in yeast: fifteen sulfa drugs compete with p-aminobenzoate in Saccharomyces cerevisiae. FEMS Microbiol Lett 199(2):181-4
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91