Standard Name	ABP1 1, 2
Systematic Name	YCR088W
Feature Type	ORF, Verified
Description	Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences (1, 3, 4, 5)
Name Description	Actin Binding Protein 2

Chromosomal Location	ChrIII:265068 to 266846 | ORF Map | GBrowse
	Genetic position: 80 cM

	View Computational GO annotations for ABP1
Molecular Function
Manually curated	actin filament binding (IDA)
Biological Process
Manually curated	actin cortical patch assembly (IMP) protein localization (IMP)
Cellular Component
Manually curated	actin cortical patch (IDA) cell cortex (IDA)
High-throughput	cytoplasm (IDA) mating projection tip (IDA)

Classical genetics
null	actin cytoskeleton morphology: abnormal endocytosis: decreased Inp52p-delta37C-GFP distribution: abnormal Srv2p distribution: abnormal resistance to sodium chloride: decreased sporulation efficiency: decreased
overexpression	actin cytoskeleton morphology: abnormal bipolar budding pattern: increased cell size: increased inviable
unspecified	Ark1p distribution: abnormal Prk1p distribution: abnormal
Large-scale survey
null	competitive fitness: decreased endocytosis: decreased replicative lifespan: increased resistance to hygromycin B: increased resistance to spermine: increased resistance to tetramethylammonium: increased resistance to bleomycin: decreased resistance to camptothecin: decreased resistance to cycloheximide: decreased resistance to caffeine: decreased starvation resistance: decreased toxin resistance: decreased viable
overexpression	inviable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	155 total interaction(s) for 78 unique genes/features.
Physical Interactions	Affinity Capture-MS: 25 Affinity Capture-RNA: 3 Affinity Capture-Western: 12 Co-fractionation: 3 Co-localization: 4 FRET: 2 PCA: 1 Protein-peptide: 13 Reconstituted Complex: 2 Two-hybrid: 28
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 36 Phenotypic Enhancement: 2 Positive Genetic: 3 Synthetic Growth Defect: 6 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 11 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:265068 to 266846 | ORF Map | GBrowse
	Genetic position: 80 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1779 265068..266846 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000684