ABF2/YMR072W Summary

ABF2 BASIC INFORMATION

Standard Name	ABF2 1
Systematic Name	YMR072W
Feature Type	ORF, Verified
Description	Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation (1, 2, 3)
Name Description	ARS-Binding Factor 1

GO Annotations	All ABF2 GO evidence and references
	View Computational GO annotations for ABF2
Molecular Function
Manually curated	DNA bending activity (IDA) DNA binding (IDA)
Biological Process
Manually curated	mitochondrial genome maintenance (IMP) mitochondrion inheritance (IMP)
Cellular Component
Manually curated	mitochondrial chromosome (IDA) mitochondrial nucleoid (IDA)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All ABF2 Phenotype details and references
Classical genetics
null	mitochondrial genome maintenance: abnormal
overexpression	budding index: abnormal cell cycle progression in G2 phase: abnormal
Large-scale survey
null	glycogen accumulation: decreased competitive fitness: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased resistance to ethanol: decreased respiratory growth: decreased rate respiratory growth: absent utilization of carbon source: decreased viable
overexpression	vegetative growth: decreased

Interactions	ABF2 All interactions details and references
	59 total interaction(s) for 42 unique genes/features.
Physical Interactions	Affinity Capture-MS: 38 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Co-fractionation: 1 PCA: 1
Genetic Interactions	Dosage Rescue: 5 Phenotypic Enhancement: 4 Phenotypic Suppression: 2 Synthetic Growth Defect: 1 Synthetic Lethality: 1

Sequence Information

ChrXIII:411568 to 412119 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..552	411568..412119	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004676

ABF2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ABF2

NOMENCLATURE CONFLICT NOTE

Name	Relevance	Description
HIM1	Nomenclature conflict	HIM1 has been used to refer to both ABF2/YMR072W, which encodes a mitochondrial DNA-binding protein, and HIM1/YDR317W that plays a role in mismatch repair.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ABF2]

1)	Diffley JF and Stillman B (1991) A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria. Proc Natl Acad Sci U S A 88(17):7864-8
2)	MacAlpine DM, et al. (1998) The high mobility group protein Abf2p influences the level of yeast mitochondrial DNA recombination intermediates in vivo. Proc Natl Acad Sci U S A 95(12):6739-43
3)	Cho JH, et al. (2001) The modulation of the biological activities of mitochondrial histone Abf2p by yeast PKA and its possible role in the regulation of mitochondrial DNA content during glucose repression. Biochim Biophys Acta 1522(3):175-86

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