AAP1/YHR047C Summary Help

AAP1 BASIC INFORMATION

Standard Name AAP1 1
Systematic Name YHR047C
Alias AAP1'
Feature Type ORF, Verified
Description Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation (1 and see Summary Paragraph)
Name Description Arginine/alanine AminoPeptidase 1
GO Annotations All AAP1 GO evidence and references
    View Computational GO annotations for AAP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Mutant Phenotype All AAP1 Phenotype details and references
Large-scale survey
null
Interactions AAP1 All interactions details and references
7 total interaction(s) for 6 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
Sequence Information
ChrVIII:201303 to 198733 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2571 201303..198733 2005-11-07 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001089

AAP1 RESOURCES

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Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for AAP1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
ATP8Nomenclature conflictThe gene name AAP1 has been used to refer to both Q0080 and YHR047C.

SUMMARY PARAGRAPH for AAP1

Aap1p is an alanine/arginine aminopeptidase that localizes to the nucleus and cytoplasm (1, 2). Aap1p acts as a positive regulator of glycogen accumulation, either directly or indirectly (1). AAP1 is constitutively expressed under normal growth conditions (1), and is induced in a Gcn4p-dependent manner in response to histidine starvation (3). AAP1 expression is decreased in an mpk1 null mutant relative to wild-type in response to linoleic acid hydroperoxide (LoaOOH) (4).

aap1 null mutants are viable, but accumulate less glycogen than wild type at the diauxic shift when glucose is depleted from the medium, and display a slight dampening of the heat shock response (1). Overproduction of Aap1p results in hyperaccumulation of glycogen, an increased growth rate on acetate-based medium, and increased expression of the HSP70-related SSA3 gene during entry into stationary phase. Overproduction also suppresses the temperature-sensitive growth defect of an spr5-27 mutant on non-fermentable carbon sources (1).

Aap1p is a member of the M1 family of metalloaminopeptidases, which includes Ape2p and bacterial and mammalian membrane alanyl aminopeptidases, mammalian glutamyl aminopeptidases and leukotriene A-4 hydrolases (human LTA4H). Aap1p also has similarity to Aspergillus niger ApsA and to mouse pre-B cell antigen BPI (1, 5).

Last updated: 2006-04-05

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for AAP1]

1) Caprioglio DR, et al.  (1993) Isolation and characterization of AAP1. A gene encoding an alanine/arginine aminopeptidase in yeast. J Biol Chem 268(19):14310-5
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Natarajan K, et al.  (2001) Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Mol Cell Biol 21(13):4347-68
4) Alic N, et al.  (2003) Lipid hydroperoxides activate the mitogen-activated protein kinase Mpk1p in Saccharomyces cerevisiae. J Biol Chem 278(43):41849-55
5) Hinnebusch AG and Natarajan K  (2002) Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress. Eukaryot Cell 1(1):22-32