AAD3/YCR107W Summary

AAD3/YCR107W Summary

Standard Name	AAD3 1
Systematic Name	YCR107W
Feature Type	ORF, Verified
Description	Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD3 has a paralog, AAD15, that arose from a segmental duplication (2, 3, 4)
Name Description	Aryl-Alcohol Dehydrogenase 1, 2

Chromosomal Location	ChrIII:313890 to 314981 \| ORF Map \| GBrowse

Gene Ontology Annotations All AAD3 GO evidence and references

	View Computational GO annotations for AAD3
Molecular Function
Manually curated	aryl-alcohol dehydrogenase (NAD+) activity (ISS)
Biological Process
Manually curated	cellular aldehyde metabolic process (ISS)
Cellular Component
Manually curated	cellular_component unknown (ND)

Mutant phenotypes All AAD3 Phenotype evidence and references

Classical genetics
null	viable
Large-scale survey
null	competitive fitness: increased resistance to cycloheximide: decreased resistance to quinine: increased resistance to paromomycin: decreased resistance to benzo[a]pyrene: decreased starvation resistance: decreased
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All AAD3 Interaction evidence and references

	7 total interaction(s) for 7 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Protein-RNA: 1 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 3 Synthetic Growth Defect: 1
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DIP \| DRYGIN \| GeneMANIA \| InterologFinder

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All AAD3 Protein evidence and references

Localization	YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrIII:313890 to 314981 | |

SGD ORF map

Last Update

Coordinates: 2011-02-03 | Sequence: 2000-09-13

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1092	313890..314981	2011-02-03	2000-09-13

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000000704

References cited on this page View Complete Literature Guide for AAD3

1)	Delneri D, et al. (1999) Analysis of the seven-member AAD gene set demonstrates that genetic redundancy in yeast may be more apparent than real. Genetics 153(4):1591-600
2)	Delneri D, et al. (1999) Disruption of seven hypothetical aryl alcohol dehydrogenase genes from Saccharomyces cerevisiae and construction of a multiple knock-out strain. Yeast 15(15):1681-9
3)	Dickinson JR, et al. (2003) The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae. J Biol Chem 278(10):8028-34
4)	Katju V, et al. (2009) Variation in gene duplicates with low synonymous divergence in Saccharomyces cerevisiae relative to Caenorhabditis elegans. Genome Biol 10(7):R75