AAC3/YBR085W Summary

AAC3 BASIC INFORMATION

Standard Name	AAC3
Systematic Name	YBR085W
Alias	ANC3
Feature Type	ORF, Verified
Description	Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration (1, 2)
Name Description	ADP/ATP Carrier 1

GO Annotations	All AAC3 GO evidence and references
	View Computational GO annotations for AAC3
Molecular Function
Manually curated	ATP:ADP antiporter activity (ISA)
Biological Process
Manually curated	anaerobic respiration (IEP, IGI) heme biosynthetic process (IGI) transmembrane transport (ISA)
Cellular Component
Manually curated	mitochondrial inner membrane (ISA)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All AAC3 Phenotype details and references
Classical genetics
null	respiratory growth: normal viable
overexpression	cell cycle progression in G1 phase: abnormal
Large-scale survey
null	resistance to sulfanilamide: decreased viable
overexpression	vegetative growth: decreased

Interactions	AAC3 All interactions details and references
	19 total interaction(s) for 18 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 1 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 1

Sequence Information

ChrII:415977 to 416900 | |

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..924	415977..416900	2004-07-16	1997-01-28

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000289

AAC3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for AAC3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for AAC3]

1)	Kolarov J, et al. (1990) A third ADP/ATP translocator gene in yeast. J Biol Chem 265(21):12711-6
2)	Chen XJ (2004) Sal1p, a calcium-dependent carrier protein that suppresses an essential cellular function associated With the Aac2 isoform of ADP/ATP translocase in Saccharomyces cerevisiae. Genetics 167(2):607-17

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