NAT3/YPR131C Summary

NAT3 BASIC INFORMATION

Standard Name	NAT3
Systematic Name	YPR131C
Alias	NAA20 1
Feature Type	ORF, Verified
Description	Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met (2, 3)
Name Description	N-terminal AcetylTransferase

GO Annotations	All NAT3 GO evidence and references
	View Computational GO annotations for NAT3
Molecular Function
Manually curated	peptide alpha-N-acetyltransferase activity (IMP, ISS)
Biological Process
Manually curated	cytoskeleton organization (IGI, IMP) mitochondrion inheritance (IGI, IMP) N-terminal peptidyl-methionine acetylation (IMP)
Cellular Component
Manually curated	NatB complex (TAS)
High-throughput	cytoplasm (IDA)

Mutant Phenotype	All NAT3 Phenotype details and references
Large-scale survey
null	acid pH resistance: decreased budding pattern: abnormal cell shape: abnormal glycogen accumulation: increased chromosome/plasmid maintenance: decreased competitive fitness: decreased fermentative growth: decreased rate haploinsufficient heat sensitivity: increased resistance to hygromycin B: decreased resistance to oleate: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to benomyl: decreased resistance to doxorubicin: decreased telomere length: increased viable

Interactions	NAT3 All interactions details and references
	24 total interaction(s) for 18 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 1
Genetic Interactions	Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 5 Synthetic Rescue: 2

Sequence Information

ChrXVI:794494 to 793907 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-21 | Sequence: 2003-05-23

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..588	794494..793907	2004-07-21	2003-05-23

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006335

NAT3 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for NAT3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NAT3]

1)	Polevoda B, et al. (2009) A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. BMC Proc 3 Suppl 6:S2
2)	Singer JM and Shaw JM (2003) Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast. Proc Natl Acad Sci U S A 100(13):7644-9
3)	Polevoda B and Sherman F (2003) Composition and function of the eukaryotic N-terminal acetyltransferase subunits. Biochem Biophys Res Commun 308(1):1-11

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.