HOS1/YPR068C Summary Help

HOS1 BASIC INFORMATION

Standard Name HOS1
Systematic Name YPR068C
Feature Type ORF, Verified
Description Putative class I histone deacetylase (HDAC) with sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; deletion results in increased histone acetylation at rDNA repeats; interacts with the Tup1p-Ssn6p corepressor complex (1, 2, 3 and see Summary Paragraph)
Name Description Hda One Similar 1
GO Annotations All HOS1 GO evidence and references
    View Computational GO annotations for HOS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All HOS1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
overexpression
Interactions HOS1 All interactions details and references
  View additional details at BioGRID
40 total interaction(s) for 37 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 3
  • Two-hybrid: 1
Genetic Interactions
  • Negative Genetic: 25
  • Positive Genetic: 4
  • Synthetic Growth Defect: 5
  • Synthetic Rescue: 2
Sequence Information
ChrXVI:684350 to 682938 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-07-21 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1413 684350..682938 2004-07-21 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000006272

HOS1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for HOS1

SUMMARY PARAGRAPH for HOS1

HOS1 encodes a histone deacetylase (1). Covalent modifications of histones, including acetylation and deacetylation, are implicated in transcriptional regulation in yeast and other eukaryotes, and have been reviewed in 4 and 5. Four other histone deactylases, Rpd3p, Hda1p, Hos2p, and Hos3p, have been identified in yeast; all share sequence similarity (1). Different yeast histone deacetylase complexes affect transcription of distinct, partially overlapping sets of genes (1, 5).

Last updated: 2000-01-10

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HOS1]

1) Rundlett SE, et al.  (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8
2) Robyr D, et al.  (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46
3) Davie JK, et al.  (2003) Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo. J Biol Chem 278(50):50158-62
4) Mizzen C, et al.  (1998) Signaling to chromatin through histone modifications: how clear is the signal? Cold Spring Harb Symp Quant Biol 63:469-81
5) Suka N, et al.  (1998) The regulation of gene activity by histones and the histone deacetylase RPD3. Cold Spring Harb Symp Quant Biol 63():391-9