PDE2/YOR360C Summary Help

PDE2 BASIC INFORMATION

Standard Name PDE2 1
Systematic Name YOR360C
Alias SRA5 2
Feature Type ORF, Verified
Description High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon (1, 3, 4, 5)
Name Description PhosphoDiEsterase 6
GO Annotations All PDE2 GO evidence and references
    View Computational GO annotations for PDE2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Mutant Phenotype All PDE2 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Interactions PDE2 All interactions details and references
73 total interaction(s) for 56 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • PCA: 2
Genetic Interactions
  • Dosage Rescue: 35
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 13
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 8
  • Synthetic Rescue: 7
Sequence Information
ChrXV:1014819 to 1013239 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 220 cM
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1581 1014819..1013239 2006-01-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005887

PDE2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for PDE2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PDE2]

1) Sass P, et al.  (1986) Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 83(24):9303-7
2) Wilson RB and Tatchell K  (1988) SRA5 encodes the low-Km cyclic AMP phosphodiesterase of Saccharomyces cerevisiae. Mol Cell Biol 8(1):505-10
3) Nikawa J, et al.  (1987) Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae. Mol Cell Biol 7(10):3629-36
4) Wilson RB, et al.  (1993) The pde2 gene of Saccharomyces cerevisiae is allelic to rca1 and encodes a phosphodiesterase which protects the cell from extracellular cAMP. FEBS Lett 325(3):191-5
5) Namy O, et al.  (2002) Translational readthrough of the PDE2 stop codon modulates cAMP levels in Saccharomyces cerevisiae. Mol Microbiol 43(3):641-52
6) Uno I, et al.  (1983) Characterization of a cyclic nucleotide phosphodiesterase-deficient mutant in yeast. J Biol Chem 258(6):3539-42