ASE1/YOR058C Summary

ASE1 BASIC INFORMATION

Standard Name	ASE1
Systematic Name	YOR058C
Alias	YOR29-09
Feature Type	ORF, Verified
Description	Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate (1, 2, 3)
Name Description	Anaphase Spindle Elongation 4

GO Annotations	All ASE1 GO evidence and references
	View Computational GO annotations for ASE1
Molecular Function
Manually curated	microtubule binding (IDA)
Biological Process
Manually curated	cytokinesis, completion of separation (IMP) microtubule bundle formation (IDA) mitotic anaphase B (IMP) mitotic spindle elongation (IGI, IMP) mitotic spindle stabilization (IMP) spindle midzone assembly (IMP) spindle pole body separation (IGI)
Cellular Component
Manually curated	nuclear microtubule (IDA) spindle (IDA) spindle midzone (IDA)

Mutant Phenotype	All ASE1 Phenotype details and references
Classical genetics
conditional	spindle morphology: abnormal
misexpression	cell cycle progression: delayed
null	cytokinesis: abnormal spindle morphology: abnormal toxin resistance: increased
overexpression	cell cycle passage through the metaphase-anaphase transition: delayed spindle morphology: abnormal
Large-scale survey
null	chromosome/plasmid maintenance: decreased viable

Interactions	ASE1 All interactions details and references
	119 total interaction(s) for 67 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Biochemical Activity: 3 Protein-RNA: 1 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 24 Phenotypic Suppression: 4 Synthetic Growth Defect: 20 Synthetic Lethality: 55 Synthetic Rescue: 1

Sequence Information

ChrXV:436347 to 433690 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2658	436347..433690	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005584

ASE1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ASE1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ASE1]

1)	Juang YL, et al. (1997) APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle. Science 275(5304):1311-4
2)	Schuyler SC, et al. (2003) The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins. J Cell Biol 160(4):517-28
3)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
4)	Pellman D, et al. (1995) Two microtubule-associated proteins required for anaphase spindle movement in Saccharomyces cerevisiae. J Cell Biol 130(6):1373-85

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.