AAH1/YNL141W Summary

AAH1 BASIC INFORMATION

Standard Name	AAH1 1
Systematic Name	YNL141W
Feature Type	ORF, Verified
Description	Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome (1, 2, 3)
Name Description	Adenine AminoHydrolase 1

GO Annotations	All AAH1 GO evidence and references
	View Computational GO annotations for AAH1
Molecular Function
Manually curated	adenine deaminase activity (IDA, IMP)
Biological Process
Manually curated	adenine catabolic process (IDA, IMP) hypoxanthine salvage (IDA, IMP) purine salvage (IDA, IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	salvage pathways of adenine, hypoxanthine, and their nucleosides salvage pathways of purines and their nucleosides superpathway of purine biosynthesis and salvage pathways

Mutant Phenotype	All AAH1 Phenotype details and references
Classical genetics
null	hypoxanthine accumulation: decreased inosine accumulation: decreased inosine phosphates accumulation: decreased resistance to 6-hydroxylaminopurine: decreased
Large-scale survey
null	resistance to selenomethionine: increased viable

Interactions	AAH1 All interactions details and references
	14 total interaction(s) for 11 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Two-hybrid: 1
Genetic Interactions	Phenotypic Enhancement: 2 Synthetic Growth Defect: 4 Synthetic Lethality: 4

Sequence Information

ChrXIV:359598 to 360641 | |

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1044	359598..360641	2005-11-07	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005085

AAH1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for AAH1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for AAH1]

1)	Woods RA, et al. (1984) Adenine phosphoribosyltransferase mutants in Saccharomyces cerevisiae. J Gen Microbiol 130(10):2629-37
2)	Guetsova ML, et al. (1997) The isolation and characterization of Saccharomyces cerevisiae mutants that constitutively express purine biosynthetic genes. Genetics 147(2):383-97
3)	Escusa S, et al. (2006) Proteasome- and SCF-dependent degradation of yeast adenine deaminase upon transition from proliferation to quiescence requires a new F-box protein named Saf1p. Mol Microbiol 60(4):1014-25

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