KNS1/YLL019C Summary

KNS1 BASIC INFORMATION

Standard Name	KNS1
Systematic Name	YLL019C
Feature Type	ORF, Verified
Description	Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues (1 and see Summary Paragraph) Also known as: L124
Name Description	protein KiNaSe

GO Annotations	All KNS1 GO evidence and references
	View Computational GO annotations for KNS1
Molecular Function
Manually curated	protein serine/threonine kinase activity (IDA, IMP) protein tyrosine kinase activity (IDA, IMP)
Biological Process
Manually curated	protein amino acid phosphorylation (IDA)
Cellular Component
Manually curated	cellular_component unknown (ND)

Regulatory Role
Regulatory modules	predicted: cellcycle ( 239 )

Mutant Phenotype	All KNS1 Phenotype details and references
Large-scale survey
null	filamentous growth: decreased invasive growth: absent resistance to oleate: decreased viable

Interactions	KNS1 All interactions details and references
	31 total interaction(s) for 31 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Biochemical Activity: 6 Two-hybrid: 6
Genetic Interactions	Phenotypic Enhancement: 3 Phenotypic Suppression: 9 Synthetic Lethality: 1

Sequence Information

ChrXII:107898 to 105685 | |

Note: this feature is encoded on the Crick strand.

This feature contains embedded feature(s): YLL019W-A

Genetic position: -28 cM

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2214	107898..105685	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003942

KNS1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for KNS1

SUMMARY PARAGRAPH for KNS1

KNS1 encodes a member of the LAMMER family of protein kinases, a conserved family of eukaryotic kinases so named because they share the amino acid motif "LAMMER" (2). As with other LAMMER protein kinases, Kns1p would be classified as a serine/threonine kinase based on amino acid sequence, but is actually able to phosphorylate tyrosine as well (2). Kns1p has autophosphorylation activity in vitro (2). The carboxy-terminus of Kns1p has similarity to other protein kinases such as Cdc2p of S. pombe and Cdc28p of S. cerevisiae (1). Cells with KNS1 knocked out have no readily detectable phenotype (1).

Last updated: 1999-09-01

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for KNS1]

1)	Padmanabha R, et al. (1991) The KNS1 gene of Saccharomyces cerevisiae encodes a nonessential protein kinase homologue that is distantly related to members of the CDC28/cdc2 gene family. Mol Gen Genet 229(1):1-9
2)	Lee K, et al. (1996) Activity and autophosphorylation of LAMMER protein kinases. J Biol Chem 271(44):27299-303

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