SPE1/YKL184W Summary

SPE1 BASIC INFORMATION

Standard Name	SPE1
Systematic Name	YKL184W
Alias	ORD1 , SPE10 1
Feature Type	ORF, Verified
Description	Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation (2, 3, 4, 5)
Name Description	SPErmidine auxotroph 6

GO Annotations	All SPE1 GO evidence and references
	View Computational GO annotations for SPE1
Molecular Function
Manually curated	ornithine decarboxylase activity (IDA)
Biological Process
Manually curated	pantothenate biosynthetic process (IMP) putrescine biosynthetic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	putrescine biosynthesis superpathway of polyamine biosynthesis

Mutant Phenotype	All SPE1 Phenotype details and references
Classical genetics
null	auxotrophy spermine accumulation: absent spermidine accumulation: absent putrescine accumulation: absent reactive oxygen species accumulation: increased chronological lifespan: decreased necrotic cell death: increased COX4-EGFP accumulation: increased GFP-Rap1 distribution: abnormal
Large-scale survey
null	viable

Interactions	SPE1 All interactions details and references
	12 total interaction(s) for 10 unique genes/features.
Physical Interactions	Biochemical Activity: 3 Reconstituted Complex: 1
Genetic Interactions	Phenotypic Enhancement: 2 Phenotypic Suppression: 2 Synthetic Growth Defect: 1 Synthetic Lethality: 1 Synthetic Rescue: 2

Sequence Information

ChrXI:96762 to 98162 | |

Genetic position: -130.3 cM

Last Update

Coordinates: 2004-02-13 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1401	96762..98162	2004-02-13	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001667

SPE1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for SPE1

NOMENCLATURE CONFLICT NOTE

Name	Relevance	Description
IXR1	Nomenclature conflict	ORD1 has been used in the literature to refer to both IXR1/YKL032C, which encodes a DNA binding protein and SPE1/YKL184W, which encodes a ornithine decarboxylase.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SPE1]

1)	Xie QW, et al. (1990) Ornithine decarboxylase in Saccharomyces cerevisiae: chromosomal assignment and genetic mapping of the SPE1 gene. Yeast 6(6):455-60
2)	Toth C and Coffino P (1999) Regulated degradation of yeast ornithine decarboxylase. J Biol Chem 274(36):25921-6
3)	Fonzi WA and Sypherd PS (1987) The gene and the primary structure of ornithine decarboxylase from Saccharomyces cerevisiae. J Biol Chem 262(21):10127-33
4)	Fonzi WA (1989) Biochemical and genetic characterization of the structure of yeast ornithine decarboxylase. Biochem Biophys Res Commun 162(3):1409-16
5)	Eisenberg T, et al. (2009) Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11(11):1305-14
6)	Whitney PA and Morris DR (1978) Polyamine auxotrophs of Saccharomyces cerevisiae. J Bacteriol 134(1):214-20

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