RAM2/YKL019W Summary

RAM2 BASIC INFORMATION

Standard Name	RAM2
Systematic Name	YKL019W
Feature Type	ORF, Verified
Description	Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor (1, 2, 3, 4)
Name Description	RAS protein and A-factor Maturation

GO Annotations	All RAM2 GO evidence and references
	View Computational GO annotations for RAM2
Molecular Function
Manually curated	CAAX-protein geranylgeranyltransferase activity (IDA) protein farnesyltransferase activity (IDA) protein geranylgeranyltransferase activity (IDA)
Biological Process
Manually curated	peptide pheromone maturation (IDA) protein amino acid farnesylation (IDA) protein amino acid geranylgeranylation (IDA)
Cellular Component
Manually curated	CAAX-protein geranylgeranyltransferase complex (IDA) protein farnesyltransferase complex (IDA)

Pathways	protein modifications

Mutant Phenotype	All RAM2 Phenotype details and references
Large-scale survey
null	inviable

Interactions	RAM2 All interactions details and references
	15 total interaction(s) for 8 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Biochemical Activity: 1 Co-purification: 1 Two-hybrid: 7
Genetic Interactions	Synthetic Growth Defect: 2

Sequence Information

ChrXI:402211 to 403161 | |

Last Update

Coordinates: 2005-12-15 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..951	402211..403161	2005-12-15	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001502

RAM2 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for RAM2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RAM2]

1)	Mayer ML, et al. (1992) CDC43 and RAM2 encode the polypeptide subunits of a yeast type I protein geranylgeranyltransferase. J Biol Chem 267(29):20589-93
2)	Gomez R, et al. (1993) Purified yeast protein farnesyltransferase is structurally and functionally similar to its mammalian counterpart. Biochem J 289 ( Pt 1)():25-31
3)	He B, et al. (1991) RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins. Proc Natl Acad Sci U S A 88(24):11373-7
4)	Kohl NE, et al. (1991) Structural homology among mammalian and Saccharomyces cerevisiae isoprenyl-protein transferases. J Biol Chem 266(28):18884-8

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