BET4/YJL031C Summary

BET4 BASIC INFORMATION

Standard Name	BET4 1
Systematic Name	YJL031C
Feature Type	ORF, Verified
Description	Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p (2)
Name Description	Blocked Early in Transport 1

GO Annotations	All BET4 GO evidence and references
	View Computational GO annotations for BET4
Molecular Function
Manually curated	Rab geranylgeranyltransferase activity (IDA)
Biological Process
Manually curated	protein amino acid geranylgeranylation (IDA)
Cellular Component
Manually curated	Rab-protein geranylgeranyltransferase complex (IDA)

Pathways	protein modifications

Mutant Phenotype	All BET4 Phenotype details and references
Classical genetics
null	inviable
overexpression	resistance to nocodazole: decreased resistance to hydroxyurea: decreased
Large-scale survey
null	inviable
overexpression	cell cycle progression: abnormal

Interactions	BET4 All interactions details and references
	8 total interaction(s) for 4 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Co-purification: 1 FRET: 1 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1

Sequence Information

ChrX:387432 to 386362 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2009-02-18 | Sequence: 2004-01-27

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3	387432..387430	2009-02-18	2004-01-27
Intron	4..90	387429..387343	2009-02-18	2004-01-27
CDS	91..1071	387342..386362	2009-02-18	2004-01-27

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003568

BET4 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for BET4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BET4]

1)	Newman AP and Ferro-Novick S (1987) Characterization of new mutants in the early part of the yeast secretory pathway isolated by a [3H]mannose suicide selection. J Cell Biol 105(4):1587-94
2)	Witter DJ and Poulter CD (1996) Yeast geranylgeranyltransferase type-II: steady state kinetic studies of the recombinant enzyme. Biochemistry 35(32):10454-63

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