DAL1/YIR027C Summary 
DAL1 BASIC INFORMATION
| Standard Name | DAL1 |
|---|---|
| Systematic Name | YIR027C |
| Feature Type | ORF, Verified |
| Description | Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression (1, 2 and see Summary Paragraph) 
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| Name Description | Degradation of Allantoin |
| GO Annotations | All DAL1 GO evidence and references |
|---|---|
| View Computational GO annotations for DAL1 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
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| Pathways |
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| Mutant Phenotype | All DAL1 Phenotype details and references |
|---|---|
| Classical genetics | |
| unspecified | |
| Large-scale survey | |
| null |
| Interactions | DAL1 All interactions details and references |
|---|---|
| View additional details at BioGRID | |
| 16 total interaction(s) for 12 unique genes/features. | |
| Genetic Interactions |
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| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|
| External Links | All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB |
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| Primary SGDID | S000001466 |
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DAL1 RESOURCES
| SGD ORF map | GBrowse |
|---|---|
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Click on histogram for expression summary
Expression Summary
ADDITIONAL INFORMATION for DAL1
SUMMARY PARAGRAPH for DAL1
About allantoin degradation
The allantoin degradation pathway, which converts allantoin to ammonia and carbon dioxide, allows S. cerevisiae to use allantoin as a sole nitrogen source. Conversion of allantoin to ammonia is carried out by the DAL1, DAL2, and DAL3 gene products, which work sequentially to generate urea (3). Urea is then degraded to ammonia in a two-step process by the DUR1,2 protein, a multifunctional single enzyme originally thought to be encoded by two tightly-linked genes (hence the name DUR1,2) (4). The allantoin catabolic pathway genes are regulated by a general signal that responds to the availability of readily utilizable nitrogen sources, and also by pathway-specific induction by allantoin or the intermediate allophanate. These regulatory effects are mediated by cis-acting DNA elements and the trans-acting factors Gln3p, Gat1p, Dal80p, Dal81p, and Dal82p (5, 6, 7, 8).
Last updated: 2007-10-03
REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DAL1]
| 1) | Buckholz RG and Cooper TG (1991) The allantoinase (DAL1) gene of Saccharomyces cerevisiae. Yeast 7(9):913-23 |
| 2) | Magasanik B (1992) "Regulation of Nitrogen Utilization." Pp. 283-317 in the Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, |
| 3) | Yoo HS, et al. (1985) Identification of the ureidoglycolate hydrolase gene in the DAL gene cluster of Saccharomyces cerevisiae. Mol Cell Biol 5(9):2279-88 |
| 4) | Cooper TG, et al. (1980) Structural analysis of the dur loci in S. cerevisiae: two domains of a single multifunctional gene. Genetics 94(3):555-80 |
| 5) | Rai R, et al. (1999) Overlapping positive and negative GATA factor binding sites mediate inducible DAL7 gene expression in Saccharomyces cerevisiae. J Biol Chem 274(39):28026-34 |
| 6) | Magasanik B and Kaiser CA (2002) Nitrogen regulation in Saccharomyces cerevisiae. Gene 290(1-2):1-18 |
| 7) | Scott S, et al. (2000) Functional domain mapping and subcellular distribution of Dal82p in Saccharomyces cerevisiae. J Biol Chem 275(10):7198-204 |
| 8) | Talibi D, et al. (1995) Cis- and trans-acting elements determining induction of the genes of the gamma-aminobutyrate (GABA) utilization pathway in Saccharomyces cerevisiae. Nucleic Acids Res 23(4):550-7 |
