PDE1/YGL248W Summary Help

PDE1 BASIC INFORMATION

Standard Name PDE1
Systematic Name YGL248W
Feature Type ORF, Verified
Description Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation (1, 2, 3, 4, 5)
Name Description PhosphoDiEsterase 3
GO Annotations All PDE1 GO evidence and references
    View Computational GO annotations for PDE1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All PDE1 Phenotype details and references
Large-scale survey
null
overexpression
Interactions PDE1 All interactions details and references
12 total interaction(s) for 8 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 2
Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 3
  • Synthetic Growth Defect: 1
  • Synthetic Haploinsufficiency: 1
  • Synthetic Rescue: 2
Sequence Information
ChrVII:35653 to 36762 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1110 35653..36762 1996-07-31 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003217

PDE1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for PDE1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PDE1]

1) Nikawa J, et al.  (1987) Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae. Mol Cell Biol 7(10):3629-36
2) Thevelein JM and de Winde JH  (1999) Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol Microbiol 33(5):904-18
3) Uno I, et al.  (1983) Characterization of a cyclic nucleotide phosphodiesterase-deficient mutant in yeast. J Biol Chem 258(6):3539-42
4) Ma P, et al.  (1999) The PDE1-encoded low-affinity phosphodiesterase in the yeast Saccharomyces cerevisiae has a specific function in controlling agonist-induced cAMP signaling. Mol Biol Cell 10(1):91-104
5) Wera S, et al.  (1997) Glucose exerts opposite effects on mRNA versus protein and activity levels of Pde1, the low-affinity cAMP phosphodiesterase from budding yeast, Saccharomyces cerevisiae. FEBS Lett 420(2-3):147-50