MTO1/YGL236C Summary Help

MTO1 BASIC INFORMATION

Standard Name MTO1
Systematic Name YGL236C
Alias IPS1 1
Feature Type ORF, Verified
Description Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants (2, 3)
Name Description Mitochondrial Translation Optimization 2
GO Annotations All MTO1 GO evidence and references
    View Computational GO annotations for MTO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All MTO1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions MTO1 All interactions details and references
  View additional details at BioGRID
97 total interaction(s) for 59 unique genes/features.
Physical Interactions
  • Protein-RNA: 1
Genetic Interactions
  • Negative Genetic: 87
  • Phenotypic Enhancement: 1
  • Positive Genetic: 7
  • Synthetic Lethality: 1
Sequence Information
ChrVII:55796 to 53787 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-07-15 | Sequence: 2004-07-15
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2010 55796..53787 2004-07-15 2004-07-15
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003205

MTO1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for MTO1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MTO1]

1) Entian KD, et al.  (1999) Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Mol Gen Genet 262(4-5):683-702
2) Colby G, et al.  (1998) MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae. J Biol Chem 273(43):27945-52
3) Umeda N, et al.  (2005) Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. J Biol Chem 280(2):1613-24