EDC1/YGL222C Summary

EDC1 BASIC INFORMATION

Standard Name	EDC1 1
Systematic Name	YGL222C
Feature Type	ORF, Verified
Description	RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress (1, 2, 3)
Name Description	Enhancer of mRNA DeCapping 1

GO Annotations	All EDC1 GO evidence and references
	View Computational GO annotations for EDC1
Molecular Function
Manually curated	mRNA binding (IDA, IPI)
Biological Process
Manually curated	deadenylation-dependent decapping of nuclear-transcribed mRNA (IDA, IGI, IPI) positive regulation of translation in response to stress (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)
High-throughput	cytoplasm (IDA)

Mutant Phenotype	All EDC1 Phenotype details and references
Classical genetics
null	heat sensitivity: increased
overexpression	resistance to cycloheximide: decreased
Large-scale survey
null	competitive fitness: decreased viable

Interactions	EDC1 All interactions details and references
	View additional details at BioGRID
	29 total interaction(s) for 24 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Affinity Capture-Western: 2
Genetic Interactions	Dosage Rescue: 4 Negative Genetic: 14 Positive Genetic: 3 Synthetic Growth Defect: 4

Sequence Information

ChrVII:81185 to 80658 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-15 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..528	81185..80658	2004-07-15	1996-07-31

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003190

EDC1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for EDC1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for EDC1]

1)	Dunckley T, et al. (2001) Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae. Genetics 157(1):27-37
2)	Schwartz D, et al. (2003) The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme. RNA 9(2):239-51
3)	Neef DW and Thiele DJ (2009) Enhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae. Mol Microbiol 73(6):1032-42

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