COX13/YGL191W Summary 
COX13 BASIC INFORMATION
| Standard Name | COX13 |
|---|---|
| Systematic Name | YGL191W |
| Feature Type | ORF, Verified |
| Description | Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP (1 and see Summary Paragraph) 
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| Name Description | Cytochrome c OXidase |
| GO Annotations | All COX13 GO evidence and references |
|---|---|
| View Computational GO annotations for COX13 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated | |
| High-throughput |
| Mutant Phenotype | All COX13 Phenotype details and references |
|---|---|
| Classical genetics | |
| null |
| Interactions | COX13 All interactions details and references |
|---|---|
| 4 total interaction(s) for 4 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| External Links | All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB |
|---|
| Primary SGDID | S000003159 |
|---|
COX13 RESOURCES
| SGD ORF map | GBrowse |
|---|---|
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Click on histogram for expression summary
Expression Summary
ADDITIONAL INFORMATION for COX13
SUMMARY PARAGRAPH for COX13
Cytochrome c oxidase catalyzes the terminal step in the electron transport chain involved in cellular respiration. This multisubunit enzyme of the mitochondrial inner membrane, also known as Complex IV, is composed of three core subunits encoded by the mitochondrial genome (Cox1p, Cox2p, and Cox3p) and eight additional subunits encoded by nuclear genes (Cox4p, Cox5Ap or Cox5Bp, Cox6p, Cox7p, Cox8p, Cox9p, Cox12p, and Cox13p) (2, 3, 4). The phenotype of a mutation affecting any of the genes encoding cytochrome c oxidase subunits, or any of the multiple genes required for expression or assembly of the subunits (reviewed in 5), is a decrease or block in respiratory growth. The inability to respire is not lethal since S. cerevisiae can grow by fermentation, but nonrespiring cells grow more slowly than respiratory-competent cells even on glucose-containing medium, resulting in smaller colony size. Such mutations causing "petite" colonies were first described by Ephrussi and colleagues around 1950 (6).
Cox13p is not required for assembly or activity of cytochrome c oxidase. However, the cox13 null mutation does cause a partial respiratory growth defect (1). Cox13p, also known as subunit VIa, may regulate cytochrome c oxidase activity through its interactions with ATP (1, 7).
Last updated: 2006-08-18
REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for COX13]
| 1) | Taanman JW and Capaldi RA (1993) Subunit VIa of yeast cytochrome c oxidase is not necessary for assembly of the enzyme complex but modulates the enzyme activity. Isolation and characterization of the nuclear-coded gene. J Biol Chem 268(25):18754-61 |
| 2) | Taanman JW and Capaldi RA (1992) Purification of yeast cytochrome c oxidase with a subunit composition resembling the mammalian enzyme. J Biol Chem 267(31):22481-5 |
| 3) | Geier BM, et al. (1995) Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method. Eur J Biochem 227(1-2):296-302 |
| 4) | Cooper CE, et al. (1991) Cytochrome c oxidase: structure, function, and membrane topology of the polypeptide subunits. Biochem Cell Biol 69(9):586-607 |
| 5) | Herrmann JM and Funes S (2005) Biogenesis of cytochrome oxidase-sophisticated assembly lines in the mitochondrial inner membrane. Gene 354:43-52 |
| 6) | EPHRUSSI B and SLONIMSKI PP (1955) Subcellular units involved in the synthesis of respiratory enzymes in yeast. Nature 176(4495):1207-8 |
| 7) | Beauvoit B, et al. (1999) ATP-regulation of cytochrome oxidase in yeast mitochondria: role of subunit VIa. Eur J Biochem 263(1):118-27 |
