CDC43/YGL155W Summary

CDC43 BASIC INFORMATION

Standard Name	CDC43 1, 2
Systematic Name	YGL155W
Alias	CAL1
Feature Type	ORF, Verified
Description	Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis (3)
Name Description	Cell Division Cycle 1

GO Annotations	All CDC43 GO evidence and references
	View Computational GO annotations for CDC43
Molecular Function
Manually curated	CAAX-protein geranylgeranyltransferase activity (IDA) protein geranylgeranyltransferase activity (IDA)
Biological Process
Manually curated	cellular calcium ion homeostasis (TAS) establishment of cell polarity (TAS) protein amino acid geranylgeranylation (IDA) small GTPase mediated signal transduction (TAS)
Cellular Component
Manually curated	CAAX-protein geranylgeranyltransferase complex (IDA) intracellular (TAS)

Pathways	protein modifications

Mutant Phenotype	All CDC43 Phenotype details and references
Classical genetics
conditional	budding: absent cell size: increased growth in exponential phase: decreased rate heat sensitivity: increased
Large-scale survey
null	inviable
repressible	cell cycle progression in G1 phase: abnormal mitochondrial morphology: abnormal

Interactions	CDC43 All interactions details and references
	12 total interaction(s) for 6 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Co-purification: 1 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 3 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Synthetic Rescue: 1

Sequence Information

ChrVII:214086 to 215216 | |

Genetic position: -99 cM

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1131	214086..215216	2004-07-20	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003123

CDC43 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CDC43

NOMENCLATURE CONFLICT NOTE

Name	Relevance	Description
CHS3	Nomenclature conflict	CAL1 has been used to refer to both CDC43/YGL155W, which encodes a subunit of protein geranylgeranyltransferase, and CHS3/YBR023C, which encodes chitin synthase 3.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CDC43]

1)	Adams AE, et al. (1990) CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae. J Cell Biol 111(1):131-42
2)	Adams, A. and Pringle, J. (1985) Personal Communication, Mortimer Map Edition 9
3)	Stirtan WG and Poulter CD (1997) Yeast protein geranylgeranyltransferase type-I: steady-state kinetics and substrate binding. Biochemistry 36(15):4552-7

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