ATE1/YGL017W Summary Help

ATE1 BASIC INFORMATION

Standard Name ATE1
Systematic Name YGL017W
Feature Type ORF, Verified
Description Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway (1 and see Summary Paragraph)
Name Description Arginyl-tRNA-protein transfErase 2
Gene Product Alias arginyl-tRNA-protein transferase 1
GO Annotations All ATE1 GO evidence and references
    View Computational GO annotations for ATE1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All ATE1 Phenotype details and references
Classical genetics
overexpression
Large-scale survey
null
overexpression
Interactions ATE1 All interactions details and references
  View additional details at BioGRID
11 total interaction(s) for 10 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-Western: 1
  • Two-hybrid: 2
Genetic Interactions
  • Negative Genetic: 3
Sequence Information
ChrVII:459859 to 461370 | ORF Map | GBrowse
Gbrowse
Genetic position: -12 cM
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1512 459859..461370 2004-07-20 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002985

ATE1 RESOURCES

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SGD ORF map
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for ATE1

SUMMARY PARAGRAPH for ATE1

ATE1 encodes a cytoplasmic arginyl transferase, responsible for transferring an L-arginyl residue from a tRNA to the N-terminus of a protein (1). Proteins with aspartate or glutamate as their N-terminal residues can act as acceptors for this posttranslational protein modification (3). The transferred arginine acts as a destabilizing residue, subjecting the acceptor protein to the ubiquitin-dependent proteolysis of the N-end rule pathway (1, 3). Cells that lack Ate1p are viable, but are unable to degrade those substrates of the N-end rule pathway that are usually processed by the arginyl transferase (1). Homologs of the yeast arginyl transferase exist in mouse, human, Arabidopsis, and Drosophila (3).

Last updated: 1999-09-01

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ATE1]

1) Balzi E, et al.  (1990) Cloning and functional analysis of the arginyl-tRNA-protein transferase gene ATE1 of Saccharomyces cerevisiae. J Biol Chem 265(13):7464-71
2) Savage M, et al.  (1983) A mutant of Saccharomyces cerevisiae defective in arginyl-tRNA-protein transferase Curr Genet 7():285-288
3) Kwon YT, et al.  (1999) Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway. Mol Cell Biol 19(1):182-93