SAD1/YFR005C Summary

SAD1 BASIC INFORMATION

Standard Name	SAD1 1 (see Nomenclature conflict Note)
Systematic Name	YFR005C
Feature Type	ORF, Verified
Description	Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle (1)
Name Description	SnRNP Assembly Defective 1

GO Annotations	All SAD1 GO evidence and references
	View Computational GO annotations for SAD1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	nuclear mRNA splicing, via spliceosome (IDA)
Cellular Component
Manually curated	nucleus (IDA)

Mutant Phenotype	All SAD1 Phenotype details and references
Large-scale survey
null	inviable
reduction of function	competitive fitness: decreased resistance to tunicamycin: increased telomere length: increased

Interactions	SAD1 All interactions details and references
	View additional details at BioGRID
	9 total interaction(s) for 9 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Co-purification: 1
Genetic Interactions	Phenotypic Enhancement: 1 Positive Genetic: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 1 Synthetic Rescue: 1

Sequence Information

ChrVI:155868 to 154522 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2003-09-26 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1347	155868..154522	2003-09-26	1996-07-31

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001901

SAD1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for SAD1

NOMENCLATURE CONFLICT NOTE

Name	Relevance	Description
RAD53	Nomenclature conflict	SAD1 has been used to refer to both RAD53/YPL153C, a checkpoint protein involved in DNA repair, and SAD1/YFR005C, a protein involved in mRNA splicing.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SAD1]

1)	Lygerou Z, et al. (1999) A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing. Mol Cell Biol 19(3):2008-20

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