RML2/YEL050C Summary

RML2 BASIC INFORMATION

Standard Name	RML2
Systematic Name	YEL050C
Feature Type	ORF, Verified
Description	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor (1, 2, 3)
Name Description	Ribosomal Mitochondrial Large 1

GO Annotations	All RML2 GO evidence and references
	View Computational GO annotations for RML2
Molecular Function
Manually curated	structural constituent of ribosome (TAS)
Biological Process
Manually curated	fatty acid metabolic process (IMP) translation (TAS)
Cellular Component
Manually curated	mitochondrial large ribosomal subunit (TAS)

Mutant Phenotype	All RML2 Phenotype details and references
Classical genetics
null	chromosome/plasmid maintenance: abnormal resistance to FK506: decreased
Large-scale survey
null	glycogen accumulation: decreased chromosome/plasmid maintenance: decreased competitive fitness: decreased mitochondrial morphology: abnormal resistance to hydroxyurea: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased resistance to doxorubicin: decreased respiratory growth: decreased rate respiratory growth: absent toxin resistance: increased toxin resistance: decreased viable

Interactions	RML2 All interactions details and references
	24 total interaction(s) for 24 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Biochemical Activity: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Synthetic Growth Defect: 14 Synthetic Lethality: 4

Sequence Information

ChrV:60851 to 59670 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1182	60851..59670	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000776

RML2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RML2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RML2]

1)	Pan C and Mason TL (1997) Functional analysis of ribosomal protein L2 in yeast mitochondria. J Biol Chem 272(13):8165-71
2)	Trotter PJ, et al. (1999) A yeast strain defective in oleic acid utilization has a mutation in the RML2 gene. Biochim Biophys Acta 1438(2):223-38
3)	Hagerman RA and Trotter PJ (2001) A mutation in the yeast mitochondrial ribosomal protein Rml2p is associated with a defect in catalase gene expression. Mol Cell Biol Res Commun 4(5):299-306

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