TCA17/YEL048C Summary

TCA17 BASIC INFORMATION

Standard Name	TCA17 1
Systematic Name	YEL048C
Feature Type	ORF, Verified
Description	Protein that interacts with subunits of the TRAPP complex and may play a role its assembly or stability; mutation is synthetically lethal with gcs1 deletion; Sedlin_N family member; human Sedlin mutations cause the skeletal disorder SEDT (1, 2, 3)
Name Description	TRAPP Complex Associated protein 17 kDa 1

GO Annotations	All TCA17 GO evidence and references
	View Computational GO annotations for TCA17
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	biological_process unknown (ND)
Cellular Component
Manually curated	Golgi apparatus (IDA) colocalizes_with TRAPP complex (IDA)
High-throughput	colocalizes_with clathrin-coated vesicle (IDA)

Mutant Phenotype	All TCA17 Phenotype details and references
Classical genetics
null	Snc1p-GFP distribution: abnormal Bet5p-13Myc distribution: abnormal GFP-Ypt31p distribution: abnormal viable
Large-scale survey
null	viable

Interactions	TCA17 All interactions details and references
	43 total interaction(s) for 24 unique genes/features.
Physical Interactions	Affinity Capture-MS: 17 Affinity Capture-Western: 7 Biochemical Activity: 1 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 4 Synthetic Growth Defect: 5 Synthetic Lethality: 7

Sequence Information

ChrV:65167 to 64709 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..459	65167..64709	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000774

TCA17 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for TCA17

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TCA17]

1)	Montpetit B and Conibear E (2009) Identification of the Novel TRAPP Associated Protein Tca17. Traffic 10(6):713-23
2)	Robinson M, et al. (2006) The Gcs1 Arf-GAP mediates Snc1,2 v-SNARE retrieval to the Golgi in yeast. Mol Biol Cell 17(4):1845-58
3)	Scrivens PJ, et al. (2009) TRAPPC2L is a Novel, Highly Conserved TRAPP-Interacting Protein. Traffic 10(6):724-36

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