MMS21/YEL019C Summary Help

MMS21 BASIC INFORMATION

Standard Name MMS21 1
Systematic Name YEL019C
Alias NSE2 2 , PSO10 3
Feature Type ORF, Verified
Description SUMO ligase involved in chromosomal organization and DNA repair; essential subunit of the Mms21-Smc5-Smc6 complex; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination (1, 4, 5)
Name Description Methyl MethaneSulfonate sensitivity 1
GO Annotations All MMS21 GO evidence and references
    View Computational GO annotations for MMS21
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All MMS21 Phenotype details and references
Classical genetics
conditional
reduction of function
Large-scale survey
null
overexpression
Interactions MMS21 All interactions details and references
26 total interaction(s) for 18 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Biochemical Activity: 2
  • Co-purification: 1
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 3
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 7
Sequence Information
ChrV:121301 to 120498 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..804 121301..120498 1996-07-31 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000745

MMS21 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for MMS21

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MMS21]

1) Prakash S and Prakash L  (1977) Increased spontaneous mitotic segregation in MMS-sensitive mutants of Saccharomyces cerevisiae. Genetics 87(2):229-36
2) Murray JM and Carr AM  (2008) Smc5/6: a link between DNA repair and unidirectional replication? Nat Rev Mol Cell Biol 9(2):177-82
3) Hoch NC, et al.  (2008) Allelism of Saccharomyces cerevisiae gene PSO10, involved in error-prone repair of psoralen-induced DNA damage, with SUMO ligase-encoding MMS21. Curr Genet 53(6):361-71
4) Montelone BA and Koelliker KJ  (1995) Interactions among mutations affecting spontaneous mutation, mitotic recombination, and DNA repair in yeast. Curr Genet 27(2):102-9
5) Zhao X and Blobel G  (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82